<p>(A-D) BrdU immunostaining of adrenal sections from female F1 mice, (A) 4 hours (n=2), (B) 6 weeks (n=2), (C) 18 weeks (n=3) and (D) 23 weeks (n=5) following 2-week BrdU infusion. Arrows in C,D indicate examples of labelled cells, which at 18 weeks were often clustered near the capsule. Scale = 100 µm. (E-H) Labelled cell distributions are shown as mean percentage (±SEM) of BrdU-positive cells in each of 10 sampling rows across the depth of the cortex (as a percentage of all the cells in the row), in left adrenal sections. Sampling positions 1-10 were rows 1-10 of a 10x10 sampling grid with row 1 including the capsule and row 10 being closest to the medulla, as described in the Materials and Methods section.</p
<p>(A) Representative confocal microscopic images of triple fluorescent staining in the DG of the hi...
<p>A, B/Representative sections show rostral hippocampal DG areas in 1×1 sections of male wild type ...
<p>A) Adrenal glands were excised, fixed and serially sectioned, and representative sections of a gl...
<p>For quantitative analysis, BrdU-labelled cells were counted in left adrenal mid-sections from 3 m...
<p>(A-D) BrdU immunostaining of adrenal sections from female F1 mice (A) 4 hours; (B) 1 week; (C) 3 ...
<p>Adrenal sections from female F1 mice treated acutely with ACTH 6 weeks after 1-week BrdU infusion...
<p>BrdU and Ki67-labelled cell numbers in control and 4 h ACTH treatment groups (n=6) of female F1 m...
Appropriate maintenance and regeneration of adult endocrine organs is important in both normal physi...
Appropriate maintenance and regeneration of adult endocrine organs is important in both normal physi...
The adrenal cortex is classically divided into three morphologically and biochemically distinct zone...
<p>A, B: Continuous labelling with 10 µM BrdU after 6 h (A) and 96 h (B) culture. C, D: Labelling af...
a<p>Surgically adrenalectomized mice were treated with SU5416 (25 mg/kg/day) or equivalent amounts o...
<p>(A) transverse section from an <i>Hdh</i><sup>Q150/Q150</sup> mouse illustrating the structure of...
<p>Mouse adrenals were dissociated to single cells and cultured using differential plating in low-at...
<p>BrdU incorporation into hypothalamic cells as a measure of cell proliferation was assessed after ...
<p>(A) Representative confocal microscopic images of triple fluorescent staining in the DG of the hi...
<p>A, B/Representative sections show rostral hippocampal DG areas in 1×1 sections of male wild type ...
<p>A) Adrenal glands were excised, fixed and serially sectioned, and representative sections of a gl...
<p>For quantitative analysis, BrdU-labelled cells were counted in left adrenal mid-sections from 3 m...
<p>(A-D) BrdU immunostaining of adrenal sections from female F1 mice (A) 4 hours; (B) 1 week; (C) 3 ...
<p>Adrenal sections from female F1 mice treated acutely with ACTH 6 weeks after 1-week BrdU infusion...
<p>BrdU and Ki67-labelled cell numbers in control and 4 h ACTH treatment groups (n=6) of female F1 m...
Appropriate maintenance and regeneration of adult endocrine organs is important in both normal physi...
Appropriate maintenance and regeneration of adult endocrine organs is important in both normal physi...
The adrenal cortex is classically divided into three morphologically and biochemically distinct zone...
<p>A, B: Continuous labelling with 10 µM BrdU after 6 h (A) and 96 h (B) culture. C, D: Labelling af...
a<p>Surgically adrenalectomized mice were treated with SU5416 (25 mg/kg/day) or equivalent amounts o...
<p>(A) transverse section from an <i>Hdh</i><sup>Q150/Q150</sup> mouse illustrating the structure of...
<p>Mouse adrenals were dissociated to single cells and cultured using differential plating in low-at...
<p>BrdU incorporation into hypothalamic cells as a measure of cell proliferation was assessed after ...
<p>(A) Representative confocal microscopic images of triple fluorescent staining in the DG of the hi...
<p>A, B/Representative sections show rostral hippocampal DG areas in 1×1 sections of male wild type ...
<p>A) Adrenal glands were excised, fixed and serially sectioned, and representative sections of a gl...