Effects on fatty acid, BCAA, and amino acid pathways in <i>db/db</i> mice treated with R419.

<p>Male <i>db/db</i> mice (8 weeks old) were PO QD dosed with vehicle or 10 mg/kg R419. Thirty minutes after oral dosing, liver, muscle, and adipose tissues and plasma were collected at 3 days (n = 6) of compound administration and analyzed at Metabolon for metabolite profiles. <i>A</i>: Heat map of fatty acid oxidation metabolites in liver, muscle, adipose, and plasma from R419-treated mice shown relative to vehicle. <i>B</i>: Heat map of intermediates of branched chain amino acid catabolism in liver, muscle, adipose, and plasma from R419-treated mice shown relative to vehicle. <i>C</i>: Heat map of amino acids in liver, muscle, adipose, and plasma from R419-treated mice shown relative to vehicle. Biochemical data were analyzed using Welch’s two-sample t-tests.