<p>Scatter plots showing the percentage of (<b>A</b>) CD4 and (<b>B</b>) CD8 T cells that are naïve (CD44<sup>lo</sup>/CD62L<sup>hi</sup>), MP (CD44<sup>hi</sup>) or are a subpopulation of MP T cells (CD44<sup>hi</sup>/Ly6C<sup>hi</sup>) for LN, Spl and BM derived from individual <i>Hoxb4</i> transgenic and wt (n = 6–8) age matched mice. Young mice are between 3–4 months and old mice are all older than 28 months. Naïve and MP populations change significantly with age, but not between <i>Hoxb4</i> and wt mice. *P<0.05, 2-tailed Student ttest. MP = memory phenotype, Wt = wild type, LN = lymph node, Spl = spleen and BM = bone marrow.</p
<p>(A) Plots depict CD44 and CD62L expression on splenic <i>Hdac1<sup>f/f</sup></i> and <i>Hdac1<sup...
It is well known that leukocyte composition, T cell phenotypes and immune function change in aged mi...
Abstract Background Despite several reports on age-related phenotypic changes of the immune system's...
<p>(<b>A</b>) Scheme of the experimental approach. CD4 MP T cells are sorted from CellTrace™ Violet ...
<p>(A) Spleen and lymph node cells were isolated from age-matched WT, <i>Nfatc2</i> KO, and <i>Tob1<...
<p>(A, B) The bar plots show the percentage of naïve CD4<sup>+</sup> T cells (A) and memory CD4<sup>...
<p>Young (2–4 mo old) or middle-aged (7–14 mo old) mice were sacrificed and spleen cell suspensions ...
We discovered a novel population of cd T cells in the mouse that accumulates with age in hematopoiet...
<p>(A-B) Flow cytometry profiles of (A) thymus and (B) spleen of <i>Usp21</i><sup>-/-</sup> and wild...
The aim of this study is to evaluate the age related changes of T lymphocyte subsets in C57BL/6 mice...
<p>Contraction of the T-cell repertoire in aged naive mice: 3 and 18mths naive B6 mice were sacrific...
<p>FACS plot of CD4<sup> +</sup> Foxp3<sup>+</sup> splenocytes (A) or CD4<sup> +</sup> Foxp3<sup>+</...
<p>(A) T cell accumulation. LN cells were obtained from MRL-<i>Fas<sup>lpr</sup></i> and control C57...
Peripheral blood leukocyte composition was measured in young, middle-aged and old C57BL/6J (B6) and ...
<p>Representative histogram plots for individual NOD (thin line) and IL-21R KO NOD (thick line) mice...
<p>(A) Plots depict CD44 and CD62L expression on splenic <i>Hdac1<sup>f/f</sup></i> and <i>Hdac1<sup...
It is well known that leukocyte composition, T cell phenotypes and immune function change in aged mi...
Abstract Background Despite several reports on age-related phenotypic changes of the immune system's...
<p>(<b>A</b>) Scheme of the experimental approach. CD4 MP T cells are sorted from CellTrace™ Violet ...
<p>(A) Spleen and lymph node cells were isolated from age-matched WT, <i>Nfatc2</i> KO, and <i>Tob1<...
<p>(A, B) The bar plots show the percentage of naïve CD4<sup>+</sup> T cells (A) and memory CD4<sup>...
<p>Young (2–4 mo old) or middle-aged (7–14 mo old) mice were sacrificed and spleen cell suspensions ...
We discovered a novel population of cd T cells in the mouse that accumulates with age in hematopoiet...
<p>(A-B) Flow cytometry profiles of (A) thymus and (B) spleen of <i>Usp21</i><sup>-/-</sup> and wild...
The aim of this study is to evaluate the age related changes of T lymphocyte subsets in C57BL/6 mice...
<p>Contraction of the T-cell repertoire in aged naive mice: 3 and 18mths naive B6 mice were sacrific...
<p>FACS plot of CD4<sup> +</sup> Foxp3<sup>+</sup> splenocytes (A) or CD4<sup> +</sup> Foxp3<sup>+</...
<p>(A) T cell accumulation. LN cells were obtained from MRL-<i>Fas<sup>lpr</sup></i> and control C57...
Peripheral blood leukocyte composition was measured in young, middle-aged and old C57BL/6J (B6) and ...
<p>Representative histogram plots for individual NOD (thin line) and IL-21R KO NOD (thick line) mice...
<p>(A) Plots depict CD44 and CD62L expression on splenic <i>Hdac1<sup>f/f</sup></i> and <i>Hdac1<sup...
It is well known that leukocyte composition, T cell phenotypes and immune function change in aged mi...
Abstract Background Despite several reports on age-related phenotypic changes of the immune system's...