Loss of CRB2 results in retinal disorganization in mice on C57BL/6J genetic background.

<p>Toluidine stained light microscopic pictures, of retina sections, from the control (<b>A</b>, <b>C</b> and <b>E</b>) and from the <i>Crb2</i>Chx10 cKO on C57BL/6J genetic background (<b>C</b>, <b>D</b> and <b>F</b>), at different ages, P10 - (<b>A</b>, <b>B</b>), 1M - (C, D), 3M - (<b>E</b>, <b>F</b>). At P10 (<b>B</b>), several photoreceptor nuclei were localized ectopically in the subretinal space. At 1M (<b>D</b>) protrusion of photoreceptor cell nuclei in the subretinal space and gaps in the outer limiting membrane were observed. At 3M (<b>F</b>) we observed thinner outer nuclear layers, with rows of photoreceptors cells protruding into the subretinal space through the outer limiting membrane and protrusions of inner nuclear layer cells into the outer nuclear layer. No abnormalities were observed in the control. GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer. Scale bar: 50 µm.