Variable lung pathology in influenza virus infected outbred mice.

<p>Diversity outbred mice were infected with 1x10⁶ pfu of influenza A/California/07/2009 virus and were harvested five days later. A, B, individual mice with similar influenza viral burden (relative M protein gene expression, lower number) but disparate weight loss (weight loss percentage, upper number). C, D, individual mice with similar weight loss but different viral burdens. E, individual mouse with extreme weight loss and high viral burden, but with minimal lung inflammation pathology. F, individual mouse with no weight loss and low viral burden, but with significant lung injury. G, histologic scoring of lung parenchymal inflammation.