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Data Protection

Study overview.

Arun K. Sasikala-Appukuttan (494685)
Hyeon O. Kim (494686)
Nikilyn J. Kinzel (494687)
Jung Joo Hong (49022)
Anthony J. Smith (494688)
Reece Wagstaff (494689)
Cavan Reilly (494690)
Michael Piatak Jr (242947)
Jeffrey D. Lifson (140183)
R. Keith Reeves (140179)
R. Paul Johnson (140187)
Ashley T. Haase (189177)
Pamela J. Skinner (49026)

Publication date

December 2013

DOI

10.1371/journal.pone.0081623.g001

Abstract

<p><i>Mamu-A1*001:01</i> rhesus macaques were vaccinated intravenously with SIVmac239Δnef and intravaginally challenged 20 weeks later with WT-SIV. Individual animal numbers are indicated at the day post-SIVΔnef vaccination (dpv, upper row) or day post-challenge with WT-SIV (dpc, lower row) that animals were evaluated.</p

Extracted data

Related items

Magnitude of SIV-specific T-cell responses in animals vaccinated with all seven rYF17D/SIV constructs.

Mauricio A. Martins (102761)
Myrna C. Bonaldo (102764)
Richard A. Rudersdorf (36132)
Shari M. Piaskowski (36134)
Eva G. Rakasz (49023)
Kim L. Weisgrau (102769)
Jessica R. Furlott (102772)
Christopher M. Eernisse (102774)
Marlon G. Veloso de Santana (102777)
Bertha Hidalgo (102781)
Thomas C. Friedrich (36124)
Maria J. Chiuchiolo (102786)
Christopher L. Parks (102790)
Nancy A. Wilson (36137)
David B. Allison (49148)
Ricardo Galler (37871)
David I. Watkins (36142)

January 2013

<p>We used the same approach described in the legend of <a href="http://www.plosone.org/article/info...

Env bAb titers in macaques immunized with DNA (D) or DNA together with purified SIV Env (D&P).

Rashmi Jalah (513403)
Viraj Kulkarni (396217)
Vainav Patel (534908)
Margherita Rosati (396218)
Candido Alicea (396222)
Jenifer Bear (534909)
Lei Yu (70258)
Yongjun Guan (376197)
Xiaoying Shen (164029)
Georgia D. Tomaras (164058)
Celia LaBranche (170898)
David C. Montefiori (108747)
Rajasekhar Prattipati (534910)
Abraham Pinter (259570)
Julian Bess Jr (534911)
Jeffrey D. Lifson (140183)
Steven G. Reed (173670)
Niranjan Y. Sardesai (49844)
David J. Venzon (50683)
Antonio Valentin (396219)
George N. Pavlakis (45947)
Barbara K. Felber (189501)

March 2014

<p>(<b>A</b>) Outline of vaccination study. Macaques (N = 4/group) were immunized 4 times (V1 to V4)...

Effect of post-challenge passive NAb immunization on primary SIV infection.

Hiroyuki Yamamoto (31403)
Miki Kawada (31404)
Akiko Takeda (31405)
Hiroko Igarashi (31406)
Tetsuro Matano (31407)

February 2013

<p>(A) List of naive controls and NAb-immunized macaques. Experiments using macaques indicated by as...

Immunization schedule for the Ad5hr-SIV trial.

Christopher T. Campbell (462105)
Sean R. Llewellyn (462106)
Thorsten Damberg (462107)
Ian L. Morgan (462108)
Marjorie Robert-Guroff (376907)
Jeffrey C. Gildersleeve (462109)

September 2013

<p>Each of the macaques underwent the same schedule. Ad5hr-SIV recombinant immunogens were administe...

Timeline of SIV challenge, SIV viral loads, and Ad vaccine immunization.

Stephanie Dorta-Estremera (409242)
Pramod N. Nehete (221188)
Guojun Yang (221194)
Hong He (221185)
Bharti P. Nehete (429902)
Kathryn K. Shelton (4672792)
Michael A. Barry (226457)
K. Jagannadha Sastry (221197)

December 2017

<p>Plasma viral loads for individual macaques at different time points after SIVmac251 challenge are...

Experimental design.

Krystelle Nganou-Makamdop (324250)
James M. Billingsley (701555)
Zachary Yaffe (5684057)
Gregory O’Connor (5684060)
Gregory K. Tharp (5684063)
Amy Ransier (3723697)
Farida Laboune (5684066)
Rodrigo Matus-Nicodemos (2937672)
Andrea Lerner (5684069)
Lavina Gharu (5684072)
Jennifer M. Robertson (4768518)
Mandy L. Ford (317065)
Martin Schlapschy (168948)
Nadine Kuhn (5684075)
Alexandra Lensch (5684078)
Jeffrey Lifson (243760)
Martha Nason (82066)
Arne Skerra (168950)
Gideon Schreiber (260836)
Steven E. Bosinger (451757)
Daniel C. Douek (121117)

September 2018

35 rhesus macaques received intrarectal challenge with SIVMAC251 at baseline. At week 8 post-infecti...

Rhesus macaques were immunized with single-cycle SIV by two different regimens.

Bin Jia (372751)
Sharon K. Ng (374882)
M. Quinn DeGottardi (374884)
Michael Piatak Jr. (140181)
Eloísa Yuste (331398)
Angela Carville (122470)
Keith G. Mansfield (140182)
Wenjun Li (41954)
Barbra A. Richardson (172638)
Jeffrey D. Lifson (140183)
David T. Evans (140189)

February 2013

<p>(A) Six animals in Group A were inoculated with 6 identical doses of scSIV at 8-week intervals. E...

Outcome of repeated marginal dose SIVmac239 IR challenges.

Mauricio A. Martins (102761)
Young C. Shin (4264840)
Lucas Gonzalez-Nieto (4102363)
Aline Domingues (4102369)
Martin J. Gutman (4102366)
Helen S. Maxwell (4102396)
Iris Castro (45088)
Diogo M. Magnani (4102390)
Michael Ricciardi (4264846)
Nuria Pedreño-Lopez (4264831)
Varian Bailey (4264834)
Dillon Betancourt (4264843)
John D. Altman (282913)
Matthias Pauthner (3075156)
Dennis R. Burton (106420)
Benjamin von Bredow (4264837)
David T. Evans (140189)
Maoli Yuan (629173)
Christopher L. Parks (102790)
Keisuke Ejima (402068)
David B. Allison (49148)
Eva Rakasz (313904)
Glen N. Barber (304532)
Saverio Capuano III (3375143)
Jeffrey D. Lifson (140183)
Ronald C. Desrosiers (140185)
David I. Watkins (36142)

July 2017

<p>A) Challenge scheme. Macaques were exposed to SIV on day 0 and subsequently bled on days 7 and 10...

Immunization scheme and delayed acquisition after intrarectal repetitive SIV<sub>mac251</sub> low dose challenges.

Iskra Tuero (286870)
Venkatramanan Mohanram (217521)
Thomas Musich (782724)
Leia Miller (782725)
Diego A. Vargas-Inchaustegui (470917)
Thorsten Demberg (470916)
David Venzon (220743)
Irene Kalisz (782726)
V. S. Kalyanaraman (782727)
Ranajit Pal (782728)
Maria Grazia Ferrari (782729)
Celia LaBranche (170898)
David C. Montefiori (108747)
Mangala Rao (147350)
Monica Vaccari (782730)
Genoveffa Franchini (384425)
Susan W. Barnett (120170)
Marjorie Robert-Guroff (376907)

August 2015

<p>(A) Immunization and challenge schedule. O = oral; IN = intranasal; IT = intratracheal; IM = intr...

Comparison of protection from homologous cell-free vs cell-associated SIV challenge afforded by inactivated whole SIV vaccines.

Heeney, Jonathan
Vries, Petra
Dubbes, Rob
Koornstra, Willem
Niphuis, H.
Haaft, Peter
Boes, Jolande
Dings, Marlinda
Morein, Bror
Osterhaus, Albert

January 1992

textabstractThis study attempted to determine if SIV vaccines could protect against challenge with p...

Protection of CD4-IgG2-treated rhesus macaques in a high-dose SIVmac239 challenge experiment.

Pascal Poignard (244468)
Brian Moldt (313901)
Karla Maloveste (313902)
Noëlie Campos (313903)
William C. Olson (128917)
Eva Rakasz (313904)
David I. Watkins (36142)
Dennis R. Burton (106420)

February 2013

<p>To maintain serum concentrations, CD4-IgG2 (or control human polyclonal IgG) was administered sub...

The Frequency of Vaccine-Induced T-Cell Responses Does Not Predict the Rate of Acquisition after Repeated Intrarectal SIVmac239 Challenges inMamu-B*08$^+$ Rhesus Macaques

Martins, M A
Gonzalez-Nieto, L
Shin, Young Ju
Domingues, A
Gutman, M J
Maxwell, H S
Magnani, D M
Ricciardi, M J
Pedreño-Lopez, N
Bailey, V K
Altman, J D
Parks, C L
Allison, David B
Ejima, Keisuke
Rakasz, E G
3rd, S Capuano,
Desrosiers, R C
Lifson, J D
Watkins, D I

August 2020

Approximately 50% of rhesus macaques (RMs) expressing the major histocompatibility complex class I (...

Comparative levels of clinical resistance observed in different groups of control and vaccinated rhesus macaques over time post-infection.

Gabriel Grimaldi Jr (580562)
Antonio Teva (580563)
Renato Porrozzi (165892)
Marcelo A. Pinto (580564)
Renato S. Marchevsky (580565)
Maria Gabrielle L. Rocha (580566)
Miriam S. Dutra (580567)
Oscar Bruña-Romero (4455109)
Ana-Paula Fernandes (580568)
Ricardo T. Gazzinelli (164680)

June 2014

†<p>The stage of <i>L. infantum</i> visceral infection detected at each assessment was assigned to o...

A single dose of SAAVI MVA-C reboosts rhesus macaques after more than 3 years post DNA-MVA prime-boost vaccination

Chege, GK
Burgers, W
Muller, T
Shephard, EG
Williamson, C
Williamson, A

January 2012

We have previously reported induction of robust immune responses in rhesus macaques following a prim...

The effect of early versus delayed challenge after vaccination in controlling SHIV 89.6P infection

Chavez, Leslie L.
Davenport, Miles P.
Shiver, John W.
Tussey, Lynda G.
Cox, Kara S.
Bachinsky, Margaret
Wang, Fubao
Huang, Lingyi
Schleif, William A.
Davies, Mary-Ellen
Tang, Aimin
Casimiro, Danilo R.
Perelson, Alan S.
Ribeiro, Ruy M.

November 2008

AbstractWe sought to determine how effectively a CD8+ T cell inducing vaccine controls SHIV-89.6P in...

Magnitude of SIV-specific T-cell responses in animals vaccinated with all seven rYF17D/SIV constructs.

Mauricio A. Martins (102761)
Myrna C. Bonaldo (102764)
Richard A. Rudersdorf (36132)
Shari M. Piaskowski (36134)
Eva G. Rakasz (49023)
Kim L. Weisgrau (102769)
Jessica R. Furlott (102772)
Christopher M. Eernisse (102774)
Marlon G. Veloso de Santana (102777)
Bertha Hidalgo (102781)
Thomas C. Friedrich (36124)
Maria J. Chiuchiolo (102786)
Christopher L. Parks (102790)
Nancy A. Wilson (36137)
David B. Allison (49148)
Ricardo Galler (37871)
David I. Watkins (36142)

January 2013

<p>We used the same approach described in the legend of <a href="http://www.plosone.org/article/info...

Env bAb titers in macaques immunized with DNA (D) or DNA together with purified SIV Env (D&P).

Rashmi Jalah (513403)
Viraj Kulkarni (396217)
Vainav Patel (534908)
Margherita Rosati (396218)
Candido Alicea (396222)
Jenifer Bear (534909)
Lei Yu (70258)
Yongjun Guan (376197)
Xiaoying Shen (164029)
Georgia D. Tomaras (164058)
Celia LaBranche (170898)
David C. Montefiori (108747)
Rajasekhar Prattipati (534910)
Abraham Pinter (259570)
Julian Bess Jr (534911)
Jeffrey D. Lifson (140183)
Steven G. Reed (173670)
Niranjan Y. Sardesai (49844)
David J. Venzon (50683)
Antonio Valentin (396219)
George N. Pavlakis (45947)
Barbara K. Felber (189501)

March 2014

<p>(<b>A</b>) Outline of vaccination study. Macaques (N = 4/group) were immunized 4 times (V1 to V4)...

Effect of post-challenge passive NAb immunization on primary SIV infection.

Hiroyuki Yamamoto (31403)
Miki Kawada (31404)
Akiko Takeda (31405)
Hiroko Igarashi (31406)
Tetsuro Matano (31407)

February 2013

<p>(A) List of naive controls and NAb-immunized macaques. Experiments using macaques indicated by as...

Immunization schedule for the Ad5hr-SIV trial.

Christopher T. Campbell (462105)
Sean R. Llewellyn (462106)
Thorsten Damberg (462107)
Ian L. Morgan (462108)
Marjorie Robert-Guroff (376907)
Jeffrey C. Gildersleeve (462109)

September 2013

<p>Each of the macaques underwent the same schedule. Ad5hr-SIV recombinant immunogens were administe...

Timeline of SIV challenge, SIV viral loads, and Ad vaccine immunization.

Stephanie Dorta-Estremera (409242)
Pramod N. Nehete (221188)
Guojun Yang (221194)
Hong He (221185)
Bharti P. Nehete (429902)
Kathryn K. Shelton (4672792)
Michael A. Barry (226457)
K. Jagannadha Sastry (221197)

December 2017

<p>Plasma viral loads for individual macaques at different time points after SIVmac251 challenge are...

Experimental design.

Krystelle Nganou-Makamdop (324250)
James M. Billingsley (701555)
Zachary Yaffe (5684057)
Gregory O’Connor (5684060)
Gregory K. Tharp (5684063)
Amy Ransier (3723697)
Farida Laboune (5684066)
Rodrigo Matus-Nicodemos (2937672)
Andrea Lerner (5684069)
Lavina Gharu (5684072)
Jennifer M. Robertson (4768518)
Mandy L. Ford (317065)
Martin Schlapschy (168948)
Nadine Kuhn (5684075)
Alexandra Lensch (5684078)
Jeffrey Lifson (243760)
Martha Nason (82066)
Arne Skerra (168950)
Gideon Schreiber (260836)
Steven E. Bosinger (451757)
Daniel C. Douek (121117)

September 2018

35 rhesus macaques received intrarectal challenge with SIVMAC251 at baseline. At week 8 post-infecti...

Rhesus macaques were immunized with single-cycle SIV by two different regimens.

Bin Jia (372751)
Sharon K. Ng (374882)
M. Quinn DeGottardi (374884)
Michael Piatak Jr. (140181)
Eloísa Yuste (331398)
Angela Carville (122470)
Keith G. Mansfield (140182)
Wenjun Li (41954)
Barbra A. Richardson (172638)
Jeffrey D. Lifson (140183)
David T. Evans (140189)

February 2013

<p>(A) Six animals in Group A were inoculated with 6 identical doses of scSIV at 8-week intervals. E...

Outcome of repeated marginal dose SIVmac239 IR challenges.

Mauricio A. Martins (102761)
Young C. Shin (4264840)
Lucas Gonzalez-Nieto (4102363)
Aline Domingues (4102369)
Martin J. Gutman (4102366)
Helen S. Maxwell (4102396)
Iris Castro (45088)
Diogo M. Magnani (4102390)
Michael Ricciardi (4264846)
Nuria Pedreño-Lopez (4264831)
Varian Bailey (4264834)
Dillon Betancourt (4264843)
John D. Altman (282913)
Matthias Pauthner (3075156)
Dennis R. Burton (106420)
Benjamin von Bredow (4264837)
David T. Evans (140189)
Maoli Yuan (629173)
Christopher L. Parks (102790)
Keisuke Ejima (402068)
David B. Allison (49148)
Eva Rakasz (313904)
Glen N. Barber (304532)
Saverio Capuano III (3375143)
Jeffrey D. Lifson (140183)
Ronald C. Desrosiers (140185)
David I. Watkins (36142)

July 2017

<p>A) Challenge scheme. Macaques were exposed to SIV on day 0 and subsequently bled on days 7 and 10...

Immunization scheme and delayed acquisition after intrarectal repetitive SIV<sub>mac251</sub> low dose challenges.

Iskra Tuero (286870)
Venkatramanan Mohanram (217521)
Thomas Musich (782724)
Leia Miller (782725)
Diego A. Vargas-Inchaustegui (470917)
Thorsten Demberg (470916)
David Venzon (220743)
Irene Kalisz (782726)
V. S. Kalyanaraman (782727)
Ranajit Pal (782728)
Maria Grazia Ferrari (782729)
Celia LaBranche (170898)
David C. Montefiori (108747)
Mangala Rao (147350)
Monica Vaccari (782730)
Genoveffa Franchini (384425)
Susan W. Barnett (120170)
Marjorie Robert-Guroff (376907)

August 2015

<p>(A) Immunization and challenge schedule. O = oral; IN = intranasal; IT = intratracheal; IM = intr...

Comparison of protection from homologous cell-free vs cell-associated SIV challenge afforded by inactivated whole SIV vaccines.

Heeney, Jonathan
Vries, Petra
Dubbes, Rob
Koornstra, Willem
Niphuis, H.
Haaft, Peter
Boes, Jolande
Dings, Marlinda
Morein, Bror
Osterhaus, Albert

January 1992

textabstractThis study attempted to determine if SIV vaccines could protect against challenge with p...

Protection of CD4-IgG2-treated rhesus macaques in a high-dose SIVmac239 challenge experiment.

Pascal Poignard (244468)
Brian Moldt (313901)
Karla Maloveste (313902)
Noëlie Campos (313903)
William C. Olson (128917)
Eva Rakasz (313904)
David I. Watkins (36142)
Dennis R. Burton (106420)

February 2013

<p>To maintain serum concentrations, CD4-IgG2 (or control human polyclonal IgG) was administered sub...

The Frequency of Vaccine-Induced T-Cell Responses Does Not Predict the Rate of Acquisition after Repeated Intrarectal SIVmac239 Challenges inMamu-B*08$^+$ Rhesus Macaques

Martins, M A
Gonzalez-Nieto, L
Shin, Young Ju
Domingues, A
Gutman, M J
Maxwell, H S
Magnani, D M
Ricciardi, M J
Pedreño-Lopez, N
Bailey, V K
Altman, J D
Parks, C L
Allison, David B
Ejima, Keisuke
Rakasz, E G
3rd, S Capuano,
Desrosiers, R C
Lifson, J D
Watkins, D I

August 2020

Approximately 50% of rhesus macaques (RMs) expressing the major histocompatibility complex class I (...

Comparative levels of clinical resistance observed in different groups of control and vaccinated rhesus macaques over time post-infection.

Gabriel Grimaldi Jr (580562)
Antonio Teva (580563)
Renato Porrozzi (165892)
Marcelo A. Pinto (580564)
Renato S. Marchevsky (580565)
Maria Gabrielle L. Rocha (580566)
Miriam S. Dutra (580567)
Oscar Bruña-Romero (4455109)
Ana-Paula Fernandes (580568)
Ricardo T. Gazzinelli (164680)

June 2014

†<p>The stage of <i>L. infantum</i> visceral infection detected at each assessment was assigned to o...

A single dose of SAAVI MVA-C reboosts rhesus macaques after more than 3 years post DNA-MVA prime-boost vaccination

Chege, GK
Burgers, W
Muller, T
Shephard, EG
Williamson, C
Williamson, A

January 2012

We have previously reported induction of robust immune responses in rhesus macaques following a prim...

The effect of early versus delayed challenge after vaccination in controlling SHIV 89.6P infection

Chavez, Leslie L.
Davenport, Miles P.
Shiver, John W.
Tussey, Lynda G.
Cox, Kara S.
Bachinsky, Margaret
Wang, Fubao
Huang, Lingyi
Schleif, William A.
Davies, Mary-Ellen
Tang, Aimin
Casimiro, Danilo R.
Perelson, Alan S.
Ribeiro, Ruy M.

November 2008

AbstractWe sought to determine how effectively a CD8+ T cell inducing vaccine controls SHIV-89.6P in...

Magnitude of SIV-specific T-cell responses in animals vaccinated with all seven rYF17D/SIV constructs.

Mauricio A. Martins (102761)
Myrna C. Bonaldo (102764)
Richard A. Rudersdorf (36132)
Shari M. Piaskowski (36134)
Eva G. Rakasz (49023)
Kim L. Weisgrau (102769)
Jessica R. Furlott (102772)
Christopher M. Eernisse (102774)
Marlon G. Veloso de Santana (102777)
Bertha Hidalgo (102781)
Thomas C. Friedrich (36124)
Maria J. Chiuchiolo (102786)
Christopher L. Parks (102790)
Nancy A. Wilson (36137)
David B. Allison (49148)
Ricardo Galler (37871)
David I. Watkins (36142)

January 2013

<p>We used the same approach described in the legend of <a href="http://www.plosone.org/article/info...

Env bAb titers in macaques immunized with DNA (D) or DNA together with purified SIV Env (D&P).

Rashmi Jalah (513403)
Viraj Kulkarni (396217)
Vainav Patel (534908)
Margherita Rosati (396218)
Candido Alicea (396222)
Jenifer Bear (534909)
Lei Yu (70258)
Yongjun Guan (376197)
Xiaoying Shen (164029)
Georgia D. Tomaras (164058)
Celia LaBranche (170898)
David C. Montefiori (108747)
Rajasekhar Prattipati (534910)
Abraham Pinter (259570)
Julian Bess Jr (534911)
Jeffrey D. Lifson (140183)
Steven G. Reed (173670)
Niranjan Y. Sardesai (49844)
David J. Venzon (50683)
Antonio Valentin (396219)
George N. Pavlakis (45947)
Barbara K. Felber (189501)

March 2014

<p>(<b>A</b>) Outline of vaccination study. Macaques (N = 4/group) were immunized 4 times (V1 to V4)...

Effect of post-challenge passive NAb immunization on primary SIV infection.

Hiroyuki Yamamoto (31403)
Miki Kawada (31404)
Akiko Takeda (31405)
Hiroko Igarashi (31406)
Tetsuro Matano (31407)

February 2013

<p>(A) List of naive controls and NAb-immunized macaques. Experiments using macaques indicated by as...