Ablation of R7BP alters mesopic but not scotopic ON RGC light responses.

<p><b>A-B.</b> Distribution of mean spike rate (B) and latency (C) of P20-21 WT (gray lines) and R7BP^−/− (black lines) ON RGCs is similar under scotopic illumination. <b>C-D.</b> Ablation of R7BP decreases the mean spike rate (D) and increases the latency (E) of P20–21 ON RGCs under mesopic illumination. <b>E.</b> Representative spike trigger average (STA) stimuli of WT (gray) and R7BP^−/− (black) ON RGCs. Inset: Corresponding receptive field as revealed by images of STAs at peak contrast, asterisks. <b>F.</b> Time-to-peak between stimulus (STA peak contrast, asterisks) and response (spike) of WT and R7BP^−/− ON RGCs. <b>G.</b> Receptive field sizes of ON RGCs in P20-21 WT and R7BP^−/− retina were similar. Error bars represent ±SEM.