<p>A) Inhibition of NEIL1 activity in the HTS of the LOPAC library by aurintricarboxylic acid (squares), ellipticine (triangles), and CGP-74514A (circles). B) Inhibition of NEIL1 activity by purine analogs P2 (circles), P6 (squares), P7 (triangles), and P8 (inverted triangles).</p
Open innovation initiatives provide opportunities for collaboration and sharing of knowledge and exp...
<p>C6 cells derived from rat glioma carrying wild type p53 were used to screen the library. (<b>A</b...
High-throughput screening (HTS) is the primary technique for new lead identification in drug discove...
<p>A) CGP-74514A, B) P2, C) P6, D) P7, E) P8 compared to no inhibitor (gray squares) or no enzyme (g...
<p>A) Inhibition of the lyase activity of various bifunctional glycosylases with purine analogs. B) ...
H igh-throughput screening (HTS) of compoundcollections is now a staple of modern drug dis-covery. I...
<div><p>Following the formation of oxidatively-induced DNA damage, several DNA glycosylases are requ...
Abstract: It is recognized that high-throughput enzyme inhibition screens often return nonspecific i...
Small molecule compound library screen: A selected library of 1105 small molecules from NIH-SRI/TAAC...
Wnt signaling is important in human development and disease, thus dysregulated β-catenin constitutes...
Following the formation of oxidatively-induced DNA damage, several DNA glycosylases are required to ...
Although small-molecule drug discovery efforts have focused largely on enzyme, receptor, and ion-cha...
Wnt signaling is important in human development and disease, thus dysregulated beta-catenin constitu...
(A) Activity heatmap representation of the 1536-well plates containing the LOPAC1280 screen compound...
Abnormal functioning of small GTPases is implicated in a variety of diseases, ranging from neurologi...
Open innovation initiatives provide opportunities for collaboration and sharing of knowledge and exp...
<p>C6 cells derived from rat glioma carrying wild type p53 were used to screen the library. (<b>A</b...
High-throughput screening (HTS) is the primary technique for new lead identification in drug discove...
<p>A) CGP-74514A, B) P2, C) P6, D) P7, E) P8 compared to no inhibitor (gray squares) or no enzyme (g...
<p>A) Inhibition of the lyase activity of various bifunctional glycosylases with purine analogs. B) ...
H igh-throughput screening (HTS) of compoundcollections is now a staple of modern drug dis-covery. I...
<div><p>Following the formation of oxidatively-induced DNA damage, several DNA glycosylases are requ...
Abstract: It is recognized that high-throughput enzyme inhibition screens often return nonspecific i...
Small molecule compound library screen: A selected library of 1105 small molecules from NIH-SRI/TAAC...
Wnt signaling is important in human development and disease, thus dysregulated β-catenin constitutes...
Following the formation of oxidatively-induced DNA damage, several DNA glycosylases are required to ...
Although small-molecule drug discovery efforts have focused largely on enzyme, receptor, and ion-cha...
Wnt signaling is important in human development and disease, thus dysregulated beta-catenin constitu...
(A) Activity heatmap representation of the 1536-well plates containing the LOPAC1280 screen compound...
Abnormal functioning of small GTPases is implicated in a variety of diseases, ranging from neurologi...
Open innovation initiatives provide opportunities for collaboration and sharing of knowledge and exp...
<p>C6 cells derived from rat glioma carrying wild type p53 were used to screen the library. (<b>A</b...
High-throughput screening (HTS) is the primary technique for new lead identification in drug discove...