Antigen-specific cytokine secreting T-cells and antibody-secreting T cells.

<div><p>A Box plots of tetanus-specific IFN-γ- (left panel) and IL-5- producing (right panel) T cells and IgG-secreting B cells (right panel) as measured by ELISPOT before (day0) and 7 days after vaccination. Boxes represent the 25th and 75th percentile and medians are indicated. Whiskers indicate the 5th and 95th percentile. ** p<0.01 (Wilcoxon signed-rank test).</p> <p>B Box plots of diphtheria-specific IFN-γ- (left panel) and IL-5- producing (right panel) T cells and IgG-secreting B cells (right panel) as measured by ELISPOT before (day0) and 7 days after vaccination. Boxes represent the 25th and 75th percentile and medians are indicated. Whiskers indicate the 5th and 95th percentile. ** p<0.01 (Wilcoxon signed-rank test).</p> <p>C Representative examples for persons without (n=3) or with high (n=3) diphtheria-specific antibody concentrations following vaccination Depicted are antibody concentrations 28 days after vaccination (black) and diphtheria-specific antibody secreting cells (ASC) 7 days after vaccination (grey).</p>