Spatiotemporal correlation of APA with parametric ultrasound imaging.

<p>(A) Temporal changes of the ROC area-under-curves (AUCs) using |Δσ|_max for detecting lesion and ΔAPA below lesion threshold (non-lesion). (B) Temporal changes of detection accuracy, sensitivity (true positive rate), and specificity (true negative rate) using cumulative extrema of log-normal parameter (|Δσ|_max) for detection of lesion and peripheral ΔAPA regions. (C) M2D images color coded by true lesion region (ΔAPA<–0.43, blue) and non-lesion ΔAPA (–0.43<ΔAPA<–0.19, green) determined from ΔAPA maps. (D) Gray-scale M2D images color coded with lesion (red) and non-lesion ΔAPA (yellow) regions determined from |Δσ|_max images. Blue time indices indicate frames during HIFU application. (E) Stacked temporal M2D images coded with lesion and non-lesion ΔAPA masks detected by |Δσ|_max.