Development of hyperplasia, mechanical allodynia and thermal hyperalgesia after CFA injection.

<p>CFA (10 µL, 0.5 mg/ml) was injected into the plantar surface of a mouse hind paw. Intraplantar injection of CFA elicited persistent hyperplasia (A), mechanical allodynia (B) and thermal hyperalgesia (C) for day 14; data, mean ± S.E.M., Saline (n = 12), CFA (n = 12); ^##<i>p</i><0.01, compared with saline (Student's <i>t</i>-test); ◊, saline; and ▪, CFA.