Regional Analysis.

<p>(A) Displays of the distribution of vascular parameters (VV, PS), transport parameters (DR – draining rate, DV – draining volume, PR – pooling rate, PV – pooling volume) and optical imaging parameters (OP_Bf – optical bright field, OP_Fl – optical fluorescence field, Col1– Col1 fibers) in hypoxic regions (top panel), ∼100 µm around hypoxic regions (middle panel), and in normoxic regions (bottom panel) of a representative tumor section from a breast cancer xenograft. (B) Tile scan of SHG microscopy of Col1 fibers of the same section, showing Col1 fiber patterns in the magnified inserts. (C) Quantifications of draining voxels in percent showing a significant increase (*<i>p-value</i> = 0.014329, N = 10) in percent draining voxels in areas surrounding hypoxic regions.