Novel <i>LMNA</i> mutation (G232V) segregates with inherited cardiac conduction disease.

<p>(<b>A</b>) Pedigree of the studied family. The pedigree shows the affection statuses, individual identifiers, and genotypes at <i>LMNA</i> c.G695T. The samples (marked by arrows) I-3, II-2, II-3, II-4 and III-1 were exome sequenced. The I-1, I-3 and II-1 samples were from healthy individuals, and the phenotype of sample III-1 was uncertain. (<b>B</b>) Sequencing result showing the heterozygous <i>LMNA</i> c.G695T (G232V) mutation. WT, wild type allele; MT, mutant allele. (<b>C</b>) Schematic of Lamin A protein. *G232V mutation in the 1B−2 linker region.