Ability of Tests to Detect Acute HIV Cases, and All HIV Cases: San Francisco Targeted Testing Programs, 2003–2008.

<p> = immunoassay. RT = rapid test. POC = point-of-care. For each test, its potential for case finding was calculated by assuming it would detect the 695 specimens which were positive by the original HIV antibody screening assay, and also fully positive on supplemental Western blot testing. These estimates thus represent the maximum clinical sensitivity that could be expected were the assay to be used in San Francisco. For specimens that were negative in the original screening assay but reactive on pooled RNA testing, the ability of each test to detect these specimens was calculated separately for the 58 Western blot-negative or -indeterminate and for the 8 Western blot positive specimens, based on the test's observed performance on specimens tested in that category. When not all specimens in a category were available for testing, the proportion of tested cases detected was multiplied by the total number of cases in the category to obtain the estimate of potential case finding. IA</p><p>“acute” specimens that were reactive on the blood plasma sample, two had been negative on a screening test of fingerstick whole blood, using the same Oraquick Advance test. Actual performance estimates for Oraquick fingerstick blood testing are reported in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0080629#pone-0080629-t002" target="_blank">Table 2</a>. among the three