High CPSF4 expression correlates with shorter overall survival in patients with lung adenocarcinoma.

<p>(<b>A</b>) Representative examples for strong, moderate, weak and negative CPSF4 expression in lung adenocarcinoma tissues. Upper panels, ×40; lower panels, ×400, from the area of the box in upper panel respectively. (<b>B</b>) Comparison of CPSF4 expression levels between lung adenocarcinoma tissues and adjacent non-malignant lung tissues by immunohistochemistry in the same patient. Representative images of paired lung adenocarcinoma tissues and adjacent non-malignant lung tissues were shown (magnification, ×400).(<b>C</b>) ROC curve analysis was used to determine the cut-off score for high expression of CPSF4 protein in lung adenocarcinoma tissues. The sensitivity and specificity for OS were plotted; <i>p</i> = 0.002. (<b>D</b>) Kaplan–Meier analysis of overall survival with high or low CPSF4 expression (<i>p</i><0.001, log-rank test). (<b>E</b>) Kaplan–Meier analysis of overall survival of male and female patients with high CPSF4 expression (<i>p</i> = 0.56).