The connected subnetwork showing decreased functional connections in the heroin-dependent individuals (HDIs) compared to the normal controls (NCs).

<p>(a) Visualization of decreased functional connections related to heroin addiction using BrainNet Viewer (<a href="http://www.nitrc.org/projects/bnv/" target="_blank">http://www.nitrc.org/projects/bnv/</a>). The width of the line indicates the <i>t</i>-value of the connection comparisons between the two groups. A single, connected subnetwork containing 19 nodes and 19 connections was determined using the network-based statistic (NBS) method. (b) Scatter plot of the integrated clustering coefficient, , against the mean functional connectivity of this connected subnetwork averaged over all subjects. (c) Same as (b) but for the integrated normalized clustering coefficient, . (d) Same as (b) but for integrated small-worldness, . The abbreviations of the regions are listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0082715#pone.0082715.s003" target="_blank">Table S2</a>.