Regulation of 11β-HSD1 by NF-κB.

<p><i>A</i>: The effects of the NF-κB inhibitor NAC on 11β-HSD1 expression in 3T3-L1 adipocytes. <i>B</i>: The effects of TNF-α on 11β-HSD1 mRNA expression in wild type MEF cells and the p65-null MEF cells. <i>C</i>: Insulin treatment decreased 11β-HSD1 mRNAs in the adipose tissue of type 2 diabetic SD rats. <i>D</i>: Insulin treatment blocked the increase in 11β-HSD1 mRNA in response to TNF-α treatment. The data are shown as the mean ± SEM of three independent experiments. “*” indicates P < 0.05 compared with the nondiabetic control group. “#” indicates P<0.05 compared with DM group. <i>NC</i>, normal control; <i>DM</i>, diabetic rats with no insulin therapy; <i>EI</i>, diabetic rats treated with insulin during early intervention study; EG, diabetic rats treated with gliclazide during early intervention study.