Demonstrates a common motif in 1800 base pairs upstream to the transcription start site of the upregulated genes.

<p>Strand + and − denotes the sense and antisense DNA sequence. The start denotes the number of base pair upstream to the transcriptional start site. p-value denotes the probability of the presence of motif by chance in the given sequence as a part of group of sequence altered by long-term hypoxic exposure. The bottom of the figure shows a cis-regulatory element for Pbx/knotted 1 homeobox transcription factor, which can bind on the common motif of the genes shown above. Bits refer to the likely hood of the presence of a particular letter of a specific motif, at a specific site, in more number of background sequences of genes altered by long-term hypoxia.