The effect of 5-HT_1A receptor in the antidepressant-like of YL-0919.

<p>Coadministration with WAY-100635 (0.3 mg/kg, s.c.) prevented YL-0919 (1.25, 2.5 mg/kg, p.o.)-induced reductions in the immobility time in TST (A) and FST (B) in mice. WAY, WAY-100635; YL, YL-0919. Mice received WAY-100635 and YL-0919 simultaneously; 60 min later, the animal were submitted to the forced swimming. Data are presented as means±SEM (n = 10/group). **<i>p</i><0.01, ***<i>p</i><0.001 versus vehicle, ^##<i>p</i><0.01 versus the same dose of YL-0919.