The effects of YL-0919 in rats exposed to 4-week stress procedure.

<p><b>A.</b> The outline of design for CUS and behavioral tests. <b>B.C.</b> The effects of YL-0919 and fluoxetine on the number of crossing and rearing. The number of crossing and rearing in stress-vehicle group were significantly decreased after 4-week exposure to chronic unpredictable stress. Daily oral administration of YL-0919 (1.25 or 5 mg/kg) and fluoxetine (10 mg/kg) reversed the inhibition of locomotor activity in CUS rats. <b>D.E.</b> The effects of YL-0919 and fluoxetine on the sucrose preference in rats before (D) and after (E) 4-week stress procedure. Four-week stress procedure caused significant decrease in sucrose preference in stress-vehicle rats compared to control non-stressed rats. Four-week treatment of YL-0919 (1.25, 2.5 mg/kg, p.o.) and fluoxetine (2.5 mg/kg, p.o.) restored the sucrose preference to normal level. <b>F.</b> The effects of YL-0919 and fluoxetine on the latency to begin eating in rats exposed to 4-week stress regime. Long-term treatment of YL-0919 (1.25 or 2.5 mg/kg, p.o.) and fluoxetine (10 mg/kg, p.o.) significantly reduced the latency to begin eating compared with vehicle-stressed rats. Flu, fiuoxetine. Fluoxetine or YL-0919 was administered p.o. prior to stress procedure. Data are presented as means±SEM (n = 8–11/group). **<i>p</i><0.01, ***<i>p</i><0.001versus control, ^#<i>p</i><0.05, ^##<i>p</i><0.01, ^###<i>p</i><0.001 versus stress.