MHC-II was upregulated in contralateral and OHT-eyes.
- Rosa de Hoz (419547)
- Beatriz I. Gallego (499404)
- Ana I. Ramírez (419550)
- Blanca Rojas (419549)
- Juan J. Salazar (419545)
- Francisco J. Valiente-Soriano (499405)
- Marcelino Avilés-Trigueros (499406)
- Maria P. Villegas-Perez (499407)
- Manuel Vidal-Sanz (93132)
- Alberto Triviño (499408)
- José M. Ramírez (419551)
Publication date
December 2013
DOIAbstract
<p>Iba-1+ and MHC-II+ cells in the NFL and RGC layer. Retinal whole-mounts. In naïve (A1-A3), contralateral (B1-B3), and OHT (C1-C3) eyes, some Iba-1+ cells displayed bipolar morphology and perivascular arrangement (arrowhead). These cells were observed mainly in the large retinal vessels (in the vicinity of the optic nerve) and in the collecting tube (in the peripheral retina) and expressed MHC-II. This MHC-II expression, constitutive in naïve eyes (A2-A3), was upregulated in contralateral (B2-B3) and OHT-eyes (C2-C3). (NFL: nerve-fibre layer; RGC: retinal ganglion-cell layer; OHT: ocular hypertension; asterisk: blood vessel; arrow: rod-microglia).</p
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