RNA expression changes of selected pro-death and pro-survival genes in study models.

<p>The fold change (FC) differences measured by qRT-PCR of selected genes in mutants compared to normals are shown at different ages. Genes belong to different functional categories: <b>A</b>) pro-death members of the extrinsic apoptotic pathway <i>CASP8</i>, <i>TNFA</i>, <i>TNFRSF1A</i>, <i>TRADD</i>; <b>B</b>) pro-survival <i>STAT3</i>, <i>NTF3</i>, <i>XIAP</i>, <i>IL10</i>. An asterisk indicates statistical significance; bars show SD of biological triplicates. Note that values on the Y-axis are not the same for all graphs, due to the highly variable FC differences in gene expression.