Prevention of platelet aggregation by Aspirin reverses thrombocytopenia and reduces LPS-induced lung inflammation in F508del mice.

<p>A. Pretreatment with Aspirin increased blood platelet counts; B. Pretreatment with Aspirin reduced plasma TXB2 levels in LPS-challenged <i>F508del</i> mice compared to LPS-challenged <i>F508del</i> mice receiving vehicle; C–D. Administration of aspirin reduced BAL neutrophils and protein levels in LPS-challenged <i>F508del</i> mice compared to LPS-challenged <i>F508del</i> mice receiving vehicle. N = 5 in each group. Data were analyzed by t-test and presented in mean ± SD. P values are listed on each panel.