<p>The brain is a common site of metastatic disease in patients with breast cancer, which has few therapeutic options and dismal outcomes. The purpose of our study was to identify common and rare events that underlie breast cancer brain metastasis. We performed deep genomic profiling, which integrated gene copy number, gene expression and DNA methylation datasets on a collection of breast brain metastases. This dataset includes array-based DNA methylation data on 32 breast brain metastasis samples, 12 non-neoplastic breast and 15 non-neoplastic brain samples using the Infinium HumanMethylation27 BeadArray (Illumina, San Diego, CA) Gene expression (GSE52604) and aCGH (Figshare) microarray data are also available.</p
Background: Breast cancer brain metastases (BrMs) are defined by complex adaptations to both adjuvan...
Treatment options for patients with brain metastases (BMs) have limited efficacy and the mortality r...
Background: Breast cancer brain metastases (BrMs) are defined by complex adaptations to both adjuvan...
<p>The brain is a common site of metastatic disease in patients with breast cancer, which has few th...
The brain is a common site of metastatic disease in patients with breast cancer, which has few thera...
abstract: The brain is a common site of metastatic disease in patients with breast cancer, which has...
The brain is a common site of metastatic disease in patients with breast cancer, which has few thera...
<p>DNA Methylation Analysis using the Infinium HumanMethylation27 BeadArray (Illumina) for 32 Breast...
Brain metastases (BM) are one the most lethal and poorly managed clinical complications in cancer pa...
<p>A) Hierarchical clustering showing 425 tumor-specific differentially methylated loci (DML). Breas...
Brain metastases (BM) are the most common brain tumors in adults occurring in up to 40% of all cance...
DNA methylation profiling has proven to be a powerful analytical tool, which can accurately identify...
In breast cancer, metastases are relatively widely distributed, with the most common sites being bon...
DNA methylation profiling has proven to be a powerful analytical tool, which can accurately identify...
DNA methylation profiling has proven to be a powerful analytical tool, which can accurately identify...
Background: Breast cancer brain metastases (BrMs) are defined by complex adaptations to both adjuvan...
Treatment options for patients with brain metastases (BMs) have limited efficacy and the mortality r...
Background: Breast cancer brain metastases (BrMs) are defined by complex adaptations to both adjuvan...
<p>The brain is a common site of metastatic disease in patients with breast cancer, which has few th...
The brain is a common site of metastatic disease in patients with breast cancer, which has few thera...
abstract: The brain is a common site of metastatic disease in patients with breast cancer, which has...
The brain is a common site of metastatic disease in patients with breast cancer, which has few thera...
<p>DNA Methylation Analysis using the Infinium HumanMethylation27 BeadArray (Illumina) for 32 Breast...
Brain metastases (BM) are one the most lethal and poorly managed clinical complications in cancer pa...
<p>A) Hierarchical clustering showing 425 tumor-specific differentially methylated loci (DML). Breas...
Brain metastases (BM) are the most common brain tumors in adults occurring in up to 40% of all cance...
DNA methylation profiling has proven to be a powerful analytical tool, which can accurately identify...
In breast cancer, metastases are relatively widely distributed, with the most common sites being bon...
DNA methylation profiling has proven to be a powerful analytical tool, which can accurately identify...
DNA methylation profiling has proven to be a powerful analytical tool, which can accurately identify...
Background: Breast cancer brain metastases (BrMs) are defined by complex adaptations to both adjuvan...
Treatment options for patients with brain metastases (BMs) have limited efficacy and the mortality r...
Background: Breast cancer brain metastases (BrMs) are defined by complex adaptations to both adjuvan...