Gene expression analysis of inflammatory and apoptosis markers.

<p>The analysis was performed on the tissue harvested from defects filled with hydroxyapatite (HA) and strontium-doped calcium phosphate (SCP) in non-OVX and OVX rats after six and 28d of implantation. Expression levels of inflammatory markers TNF-α (A) and IL-6 (B) and apoptosis marker Caspase 3 (C). Statistically significant differences (p < 0.05) are indicated by the small letters: a = significant difference between baseline non-OVX and non-OVX (HA or SCP; 6 or 28d); b = significant difference between baseline OVX and OVX (HA or SCP; 6 or 28d); c = significant difference between HA and SCP (non-OVX or OVX; 6 or 28d); d = significant difference between non-OVX and OVX (HA or SCP; 6 or 28d); e = significant difference between six days and 28d (HA or SCP; non-OVX or OVX). The results are presented as the mean ± SEM.