Cross-correlation between inter-residue distances in a set of CYP3A4 X-ray structures.

<p>Cross-correlation between the distances between the side chains in Cys₆₄/Cys₄₆₈, Cys₃₇₇/Cys₄₆₈ and Cys₆₄/Ala₁₂₁ pairs of residues observed in a set of 13 structures of CYP3A4. The distances were calculated between the sulfur atoms of cysteines or beta carbon atom of alanine. The lines represent the results of linear regression of these sets, which are characterized by the square correlation coefficients of 0.50, 0.81 and 0.62 for the plots shown in panels <b><i>a</i></b>, <b><i>b</i></b> and <b><i>c</i></b> respectively.