Decreased pulmonary cell inflammatory response in FI-A2 and G-A2 peptide vaccinated mice after RSV challenge.

<p>Mice were i.m. vaccinated with formalin inactivated RSV A2 (FI-A2) and then s.c. vaccinated with RSV A2 G peptide (FI-A2+G-A2) and control peptide (FI-A2 + L393). Two weeks following the final peptide boost, groups were challenged with live RSV A2 and the mean numbers of BAL cells/lung (A), total eosinophil counts in the BAL (B), IL-4 levels (pg/ml) (C) and IFN gamma (D) in the cell-free BAL supernatant, and viral message levels (relative genome equivalent PFU/ml) (E) at day 5 post-challenge (peak of cell infiltration) were determined. Representative data from five independent experiments are shown. * <i>p<0</i>.<i>05</i>.