Idelalisib overcomes endothelial cells and bone marrow stromal cells mediated CLL cell protection.

<p>(A) CLL cells were co-cultured with HUVEC, UV-2, NKtert and KUSA-H1 in presence or absence of 5μM idelalisib. The gates in the contour plots exemplify viable CLL cells in one representative sample. (B) The bar diagrams represent the mean relative viabilities of CLL cells co-cultured in normal conditions (control) or in presence of 5μM idelalisib with EC and BMSC. Viabilities in idelalisib-treated samples were normalized to the corresponding viabilities of control samples at the respective time-point (100%) to account for differences in spontaneous apoptosis. Displayed is mean±SEM from 7 different samples (*p<0.05; **p<0.01).