Induction of apoptosis by BmKKx2 during the erythroid differentiation of K562 cells.

<p>(A-B) K562 cells were stained with annexin V-FITC and PI and analyzed by flow cytometry. K562 cells were treated with BmKKx2, and BSA was used as the control for 48 h (A). K562 cells were treated with Ara-C (1 μM) and Ara-C (1 μM)+ BmKKx2 for 48 h (B). Flow cytometry data show representative results from one of three independent experiments. (C) Apoptotic cells were stained with annexin V-FITC and PI analyzed by flow cytometry. Values were mean ± SD from three experiments. *<i>p</i><0.05 (Student’s <i>t</i>-test).