Schematic drawing for differential regulation via β1 integrin antibodies.

<p>Comparison of the influences of activated and inhibited signaling via β1 integrin specific antibodies on the protein expression of different immunoreactivity markers. The immunoreactivity analyses of the β1 integrin-activating (12G10) or –inhibiting (mAb13) antibody-treated and aECM (artificial extracellular matrix medium) embedded hair follicle (HF) epithelium suggested a different response of the epithelial progenitors cell subpopulations on ß1 integrin signaling. The application of aECM-incorporated β1 integrin antibodies allowed distinguishing adult human epithelial progenitor cell subpopulations with distinct amplifying capacities <i>in </i><i>situ</i>, which are located in separate epithelial compartments of human scalp HFs.