SP5-2-LD increases therapeutic efficacy in a syngenic animal model.

<p>(A) C57BL/6 mice bearing syngenic LL/2 xenografts were injected i.v. with PC5-2 (phage displaying SP5-2) or control phages, and phage titers were examined in tumor tissue and the indicated organs. (B) Eight-week-old C57BL/6 mice bearing LL/2 xenografts were injected i.v. with different doxorubicin formulations twice a week for 17 days. Mice were treated with either 1 mg/kg or 2 mg/kg of SP5-2-LD, MP5-2-LD, LD, FD or PBS. In the 1 mg/kg treatment of doxorubicin, tumor size (B) and body weight (C) were measured at the time point of injection and at the indicated times thereafter. (D, E) indicate the tumor size and body weight of 2 mg/kg treatment, respectively. All data shown are on the mean averages of six mice per group. (*, p value <0.05.)