SP5-2 enhances internalization of liposomes.

<p>(A) Fluorescence microscopy was used to visualize H460 cells after incubation with either SP5-2-liposomal SRB (SP5-2-LS), MP5-2-LS or LS at the indicated temperatures. Nuclear staining was performed using DAPI (Scale bar: 30 µm). Internalization studies of SP5-2-LD and LD in H460 cells were incubated with 10 µg/ml (B) or 2.5 µg/ml (C) drugs at 37°C, respectively. Doxorubicin uptake by the cells was quantified at the indicated times, following the removal of surface-bound liposomal drugs.