Functional domain and 3D structures of the <i>human</i> HMGR.

<p>(A) <i>Human</i> HMGR consists of 888 amino acids and is divided into three domains: membrane anchor domain, linker domain, and catalytic domain. In the catalytic domain, further separated into three subdomain named as N domain, L domain, and S domain. Cis-loop which acts as HMG binding pocket is present between S and L domain. (B) Crystal structure of the <i>human</i> HMGR monomer with NAD (P), cofactor (PDB ID: 1DQA). The protein was represented as cartoon model and this figure was prepared using PyMOL.