miR-31 affected cell growth, migration, and invasion by directly targeting SATB2 in CRC.

<p>Cell growth rate (A) and colony formation (B) were measured to compare the growth difference between SW480/miR-31 cells and SW480/miR-31 cells with over-expression STAB2. The over-expression of SATB2 can significantly attenuate the promotion effects of miR-31 on cell proliferation. The wound-healing (C) and matrigel invasion (D) assays were performed to investigate the migration changes of SW480/miR-31 after the ectopic expression of SATB2. SATB2 can inhibit migration and invasion of SW480/miR-31. SW480/miR-31 denoted CRC SW480 cells with stable over-expression miR-31. * <i>p</i> < 0.05, ** <i>p</i> <0.001.