The role of the <i>SDF-1</i>-<i>CXCR4</i> pathway in the homing of MSCs.

<p>(<b>A</b>) Kidney uptake of eGFP-labeled MSCs was measured by fluorescence microscopy 48 h after systemic administration (a: MSCs<i>^CXCR4</i>^/GFP, b: MSCs^GFP, c: MSCs^{sh<i>CXCR4</i>/GFP}). Labeled cells were detected surrounding the glomerulus (arrows). (<b>B and C</b>) Chemotaxis into transplanted kidneys was measured by RT-PCR andWestern blot. Recipients treated with MSCs^GFP were used as control. ★P<0.05 vs. control. (<b>D</b>) The expression of eGFP in different organs from recipient rats was measured 48 h after infusion.