CNR1 (AAT)n influences the relationship between inflammation and neuronal atrophy in MS.

<p>A–C. Plot of interaction analysis between CNR1 genotype and previous optic neuritis (ON), analyzing RNFL thickness, MV and LCVA. A significant interaction between genotype and ON condition was found analyzing both RNFL thickness (A) and MV (B), confirming less severe neurodegenerative damage after inflammatory events in subjects with short AAT repeats. A significant interaction between the two conditions (genotype X ON) were also revealed by LCVA analysis (C), supporting the idea that the short AAT repeat genotype is associated with less severe visual impairment secondary to neuroinflammation in MS patients.