<p>Bistability exists for values of between 0.84 and 2.07. Larger values of would correspond to the decreased function of PTEN. In this case pAKT stays at a high level once it is activated. This leads to elevated mTOR signalling and tumor growth.</p
<p>(A) kcat5 is the rate constant for hydrolysis. (B) Response of the of MAPK pathway when it is dis...
(A) Diagram of the mutual inhibition between the host cell growth and synthetic gene expression. (B)...
Alterations in the tumor suppressor phosphatase and tensin homolog (PTEN) occur in a substantial pro...
<p>In the absence of the inhibitor there are two stable steady states of the double-phosphorylated s...
<p>Black and blue curves show stable steady state activity levels and ECM concentrations, depending ...
<p>(<b>A</b>) Steady-state response curves of pAKT vs insulin for different feedback strengths . . ...
a<p>The steady state(s) for the three models by scanning a)k<sub>1</sub> (SK autophosphorylation rea...
<p>Abscissas of the turning points of <i>w</i><sub><i>1</i></sub> and <i>w</i><sub><i>2</i></sub> cu...
<p>Westen blot analysis of LMMP cultured in the presence of the PTEN inhibitor bpV(phen) (200 nM and...
(A) A schematic of the phosphorylation module. Autophosphorylation and auto-dephosphorylation of the...
<p>(a) Absolutely bistable models (<i>Bistability</i>>9.5); (b) Bistable models (<i>Bistability</i>>...
<p>The values of nodes representing growth factors and transcription factors are tabled for the rele...
<p>(A) Stationary ligand level as a function of the cis-interactions strength for and . Solid line...
<p>GF (growth factor) is the bifurcation parameter that is being changed. Red and blue curves are th...
<p>We observed a two-fold reduction in PTEN mRNA expression at 24 h and 28 h compared to baseline (0...
<p>(A) kcat5 is the rate constant for hydrolysis. (B) Response of the of MAPK pathway when it is dis...
(A) Diagram of the mutual inhibition between the host cell growth and synthetic gene expression. (B)...
Alterations in the tumor suppressor phosphatase and tensin homolog (PTEN) occur in a substantial pro...
<p>In the absence of the inhibitor there are two stable steady states of the double-phosphorylated s...
<p>Black and blue curves show stable steady state activity levels and ECM concentrations, depending ...
<p>(<b>A</b>) Steady-state response curves of pAKT vs insulin for different feedback strengths . . ...
a<p>The steady state(s) for the three models by scanning a)k<sub>1</sub> (SK autophosphorylation rea...
<p>Abscissas of the turning points of <i>w</i><sub><i>1</i></sub> and <i>w</i><sub><i>2</i></sub> cu...
<p>Westen blot analysis of LMMP cultured in the presence of the PTEN inhibitor bpV(phen) (200 nM and...
(A) A schematic of the phosphorylation module. Autophosphorylation and auto-dephosphorylation of the...
<p>(a) Absolutely bistable models (<i>Bistability</i>>9.5); (b) Bistable models (<i>Bistability</i>>...
<p>The values of nodes representing growth factors and transcription factors are tabled for the rele...
<p>(A) Stationary ligand level as a function of the cis-interactions strength for and . Solid line...
<p>GF (growth factor) is the bifurcation parameter that is being changed. Red and blue curves are th...
<p>We observed a two-fold reduction in PTEN mRNA expression at 24 h and 28 h compared to baseline (0...
<p>(A) kcat5 is the rate constant for hydrolysis. (B) Response of the of MAPK pathway when it is dis...
(A) Diagram of the mutual inhibition between the host cell growth and synthetic gene expression. (B)...
Alterations in the tumor suppressor phosphatase and tensin homolog (PTEN) occur in a substantial pro...
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