Impact of HIV and TB mono- and co-infection on CD161++ CD8+ T cell frequencies.

<p>Figure 2A: FACS plots (gated on the CD3+ T cell population) show CD161 and CD8 co-staining on representative individuals from 6 different clinical groups: HIV negative and TB negative (HNTN), HIV negative with latent TB infection (HNLTBI), HIV negative with active TB (HNTP), HIV positive TB negative (HPTN), HIV positive with latent TB infection (HPLTBI) and HIV positive with active TB (HPTP). Figure 2B: Aggregate data demonstrating CD161++ CD8+ T cell frequency (median and interquartile range) in 6 different groups: HNTN (n = 18), HNLTBI (n = 16), HNTP (n = 8), HPTN (n = 13), HPLTBI (n = 15) HPTP (n = 10). P-values reported for two-sided Mann-Whitney tests, with a p-value threshold for significance of 0.01 after Bonferroni correction for 5 comparisons. Figure 2C: CD161++CD8+ T cell frequency in all subjects with HIV-infection showed no significant correlation with either CD4 count (cells/µl) or HIV viral load (copies/ml).