Acute HIV infection is associated with a lower frequency of CD161++ CD8+ T cells.

<p>Figure 3A: Graph displays CD161++ CD8+ T cell frequency in HIV negative and TB negative subjects (HNTN, n = 14), individuals with chronic HIV infection (HIV positive TB negative HPTN, n = 13), and individuals in the acute phase of HIV infection (n = 5, sample taken within 2–3 weeks of presumed infection date). CD161++CD8+ T cells are significantly lower in HPTN individuals and those with acute HIV. Figure 3B: Graph displays CD161+CD8+ T cell frequency in the same three groups of subjects; CD161+ CD8+ T cells do not show any differences between these three groups. Figure 3C: A representative FACS plot displaying the CD161++ CD8+ T cell population over time in an individual acutely infected with HIV and assessed at 5 timepoints. Both graphs show median and interquartile range; p-values are reported for two-sided Mann-Whitney tests with threshold for significance p = 0.025 after Bonferroni correction for 2 comparisons.