Human and mouse dermal microvascular endothelial cells have similar angiogenic potential <i>in vitro</i> and <i>in vivo</i>.

<p>(<b>A-D</b>) Representative photomicrographs of human dermal microvascular endothelial cells (HDMEC) and mouse dermal microvascular endothelial cells (MDMEC) stably transduced with GFP under light microscopy (<b>A</b> and <b>B</b>) and fluorescence microscopy (<b>C</b> and <b>D</b>). (<b>E</b> and <b>F</b>) Representative images of capillary sprouts formed by HDMEC (<b>E</b>) and MDMEC (<b>F</b>) on 3-D type I collagen matrices. (<b>G</b> and <b>H</b>) Photomicrographs of representative fields of GFP-immunostaining (red color) used to localize the blood vessels formed by HDMEC (<b>G</b>) and MDMEC (<b>G</b>) 14 days after implantation in immunodefficient mice. (<b>I</b>) The number of microvessels in implants populated with HDMEC or MDMEC. Microvessels were counted in 10 random microscopic fields/scaffold (200×) in 6 scaffolds per group. Results are representative of 3 independent experiments, n = 6.