µCT evaluation of the fracture calli of WT and <i>Fzd9</i>^{−<b>/</b>−} mice at days 24 and 32 post fracture.

<p>A: Bone volume/total volume (BV/TV). B: Bone mineral density (BMD) C: 3D-models of femurs at day 24 in anterior-posterior (left) and lateral view (right). The upper panel shows WT femurs and the lower panel <i>Fzd9</i>^−/− femurs. <i>Fzd9</i>^−/− mice exhibited a less mineralized callus at both investigated time points. At day 24, the geometry of the calli of <i>Fzd9</i>^−/− mice was different from WT mice, resulting in an increased moment of inertia (<i>I_x</i>) (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0084232#pone-0084232-g007" target="_blank">Figure 7C</a>).