Efficient one-pot synthesis of ethyl 2-substitued-4-methylthiazole-5-carboxylates

<p>A new and practical one-pot procedure for the synthesis of several 2-sustituted-4-methylthiazole-5-carboxylates from commercially available starting materials is described. Under mild reaction conditions, some of the products with alkyl group on the 2-amino group or with various groups on 2-substituted phenyl ring were obtained in good yields from ethyl acetoacetate, <i>N</i>-bromosuccinimide, thiourea, or its <i>N</i>-substituted derivatives in an efficient way instead of the traditional two-step reaction.