Induced expression of <sub>ddHA</sub>GCN5b(E703G) arrests parasite replication.
- Jiachen Wang (505061)
- Stacy E. Dixon (505062)
- Li-Min Ting (380340)
- Ting-Kai Liu (399053)
- Victoria Jeffers (505063)
- Matthew M. Croken (505064)
- Myrasol Calloway (505065)
- Dominique Cannella (248329)
- Mohamed Ali Hakimi (505066)
- Kami Kim (207464)
- William J. Sullivan Jr (235105)
Publication date
January 2014
DOIAbstract
<p>Doubling assays were performed to assess growth of (A) parental wild-type, (B) <sub>ddHA</sub>GCN5b, and (C) <sub>ddHA</sub>GCN5b(E703G) parasites. Intracellular parasites were physically released from host cells and an equal number of parasites were allowed to infect fresh HFF monolayers. The infected cultures were subjected to the indicated Shield concentrations for 48 hr. Parasite proliferation was monitored by quantifying the numbers of parasites in 50 random vacuoles.</p
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