Changes in the mRNA levels of the <i>CD68</i>, <i>MCP-1</i>, <i>ET-1</i>, <i>GFAP</i>, <i>TNF-α</i>, and <i>iNOS</i> genes in the optic nerve on day 3 after crushing the optic nerves.

<p>RNA was extracted from 4(placebo). Systemic simvastatin suppresses the increase significantly (n = 6 to 8 for each condition; 22 rats were used). Data are shown as the fold changes (mean ± SD) to the sham control in the mRNA expressions.