Fenofibrate upregulates the expression of PPARα-PGC-1α-phospho-The¹⁷² AMPK in <i>db/db</i> mice with VEGF inhibition.

<p>Peroxisome proliferative-activated receptor (PPAR)α, PPARγ coactivator (PGC)-1α, phospho-The¹⁷²/total AMPK and β-actin expression in the sciatic nerves of <i>db/m</i> and <i>db/db</i> mice after 12 weeks VEGFR inhibition plus fenofibrate or VEGFR inhibition alone. Representative immunohistochemical staining of PPARα and quantitative analyses of the results are shown (A and B). *<i>P</i><0.05 versus <i>db/m</i> controls. Western blot analysis of PPARα, PGC-1α, phospho-The¹⁷²/total AMPK and β-actin (C, respectively) and quantitative analyses of the results are shown. *<i>P</i><0.05 and **<i>P</i><0.01 versus <i>db/m</i> controls.