<p>Four adult woodchucks were inoculated with 1×10<sup>7</sup> or 1×10<sup>9</sup> WHV genome equivalents. Sera and PBMCs of infected woodchucks were freshly isolated at indicated time points. WHV viral loads (black dots) were quantified by real-time PCR, and percentages of PD-1+ CD8 (CD3+ CD4−) T cells (gray squares) were analyzed by FACS. LOD: lower limit of detection.</p
<p>The viral load was evaluated by quantitative real-time PCR with the detection limit of 10<sup>3</...
<p>CD8+ Tcells from previously thymectomized and CD8 depleted animals were enumerated from total PBM...
<p>Chronic WHV carrier woodchucks were dosed three times a week (TIW) for 15 weeks with placebo, or ...
<p>(A) PBMCs were isolated from naïve (n = 4), WHV infection resolved (n = 4), and untreated chronic...
<p>Six chronically WHV-infected woodchucks were treated with ETV for 23 weeks. Four of them (61792, ...
<p>(A) pre-treatment PD-1 expression on CD8 cells (CD3+CD4-) in animals from <a href="http://www.plo...
<p>Summary of WHcAg-specific (A) and WHsAg-specific (B) degranulation responses evaluated by CD107a ...
<p>Southern blot analysis was performed on the DNA obtained from the liver samples collected post-mo...
<p>At 66 months post-injection with 100 or 10<sup>10</sup> virions of WHV/tm3 (see <a href="http://w...
<p>Serum WHV DNA (A) and WHsAg (B) concentrations of different treatment groups are presented at ind...
<p>AIC649 (3.9 x 10<sup>6</sup> Units (ELISA-based titer)) or vehicle were administered i.m. twice w...
<p>AIC649 (3.9 x 10<sup>6</sup> Units (ELISA-based titer)) or vehicle were administered i.m. twice w...
<p>(A) Group geometric mean viral loads in acutely infected woodchucks treated with αPD-L1 at 1 or 1...
To determine whether the addition of a pre-S/S human vaccine increases the antiviral activity of lam...
<p>(A) Immunization schedule. Six chronically WHV-infected woodchucks (number: 61786, 61789, 61791, ...
<p>The viral load was evaluated by quantitative real-time PCR with the detection limit of 10<sup>3</...
<p>CD8+ Tcells from previously thymectomized and CD8 depleted animals were enumerated from total PBM...
<p>Chronic WHV carrier woodchucks were dosed three times a week (TIW) for 15 weeks with placebo, or ...
<p>(A) PBMCs were isolated from naïve (n = 4), WHV infection resolved (n = 4), and untreated chronic...
<p>Six chronically WHV-infected woodchucks were treated with ETV for 23 weeks. Four of them (61792, ...
<p>(A) pre-treatment PD-1 expression on CD8 cells (CD3+CD4-) in animals from <a href="http://www.plo...
<p>Summary of WHcAg-specific (A) and WHsAg-specific (B) degranulation responses evaluated by CD107a ...
<p>Southern blot analysis was performed on the DNA obtained from the liver samples collected post-mo...
<p>At 66 months post-injection with 100 or 10<sup>10</sup> virions of WHV/tm3 (see <a href="http://w...
<p>Serum WHV DNA (A) and WHsAg (B) concentrations of different treatment groups are presented at ind...
<p>AIC649 (3.9 x 10<sup>6</sup> Units (ELISA-based titer)) or vehicle were administered i.m. twice w...
<p>AIC649 (3.9 x 10<sup>6</sup> Units (ELISA-based titer)) or vehicle were administered i.m. twice w...
<p>(A) Group geometric mean viral loads in acutely infected woodchucks treated with αPD-L1 at 1 or 1...
To determine whether the addition of a pre-S/S human vaccine increases the antiviral activity of lam...
<p>(A) Immunization schedule. Six chronically WHV-infected woodchucks (number: 61786, 61789, 61791, ...
<p>The viral load was evaluated by quantitative real-time PCR with the detection limit of 10<sup>3</...
<p>CD8+ Tcells from previously thymectomized and CD8 depleted animals were enumerated from total PBM...
<p>Chronic WHV carrier woodchucks were dosed three times a week (TIW) for 15 weeks with placebo, or ...