Synthesis of a Dicyano Abietane, a Key Intermediate for the Anti-inflammatory Agent TBE-31

Evans O. Onyango (1589872)
Liangfeng Fu (1863826)
Gordon W. Gribble (1490188)

Publication date

January 2014

DOI

Abstract

The synthesis of dicyano abietane 11, a potential precursor to the biologically active tricyclic bis-cyano enone 6 (TBE-31), was accomplished in eight steps from epoxide 13. The synthesis features a Lewis acid promoted stereoselective cyclization of epoxide 13 to generate the tricyclic ring system 12 in one step

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Synthesis of a Dicyano Abietane, a Key Intermediate for the Anti-inflammatory Agent TBE-31

Abstract

Extracted data

Synthesis of a Dicyano Abietane, a Key Intermediate for the Anti-inflammatory Agent TBE-31

Abstract

Extracted data

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