Decrease of PrP<sup>Res</sup> levels in ScN2a cells.
- Natalia C. Ferreira (506057)
- Icaro A. Marques (506059)
- Wesley A. Conceição (506060)
- Bruno Macedo (506061)
- Clarice S. Machado (506062)
- Alessandra Mascarello (470305)
- Louise Domeneghini Chiaradia-Delatorre (470306)
- Rosendo Augusto Yunes (470310)
- Ricardo José Nunes (470311)
- Andrew G. Hughson (300502)
- Lynne D. Raymond (506063)
- Pedro G. Pascutti (302195)
- Byron Caughey (236055)
- Yraima Cordeiro (132712)
Publication date
January 2014
DOIAbstract
<p>ScN2a cells were treated with the compounds belonging to the L (panels A and B), G, R', R and Y (panel C) series at 10 µM. After four days of incubation with the compounds, cells were lysed, treated with PK and PrP<sup>Res</sup> was detected in the dot-blot assay with anti-PrP antibody (R30). Control bar (medium) represents intensity density of the blot from wells without compound addition, corresponding to 100% of PrP<sup>Res</sup> content. Quantification of the assay was done by integration of the density of each dot using ImageJ software. All bars had <b>*</b><i>P</i><0.05 in relation to control.</p
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