Larger significant subnetworks: network diagrams.

<p>Network edges displayed in green and red indicate positive and negative hazard ratios, respectively, for the DNAm network correlation measure corresponding to that interaction; these correspond, respectively, to an increase and decrease in ‘network interaction co-ordinatedness’ for worse disease prognosis. (a) the KIRC large subnetwork. (b) the LUAD large subnetwork. Further details about the corresponding network nodes (genes) for the top 5% of the degree distribution and top 25 significantly enriched gene sets appear in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0084573#pone.0084573.s006" target="_blank">tables S5</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0084573#pone.0084573.s007" target="_blank">6</a>.