Extracellular acidification rate (ECAR) differs in AD-A and AD-N LCLs.

<p>Basal ECAR was overall significantly higher, and the decrease in ECAR with DMNQ was also greater for the (<b>A</b>) AD LCLs as a whole, (<b>B</b>) the AD-N LCLs and (<b>C</b>) the AD-A LCLs as compared to matched controls. (<b>D</b>) The AD-A LCLs had an overall significantly higher basal ECAR than the AD-N LCLs. (<b>E</b>) Glycolytic reserve capacity was overall higher in the AD LCLs as a whole compared to the control LCLs, but was not different between (<b>F</b>) AD-N and controls. (<b>G</b>) The AD-A LCLs exhibited overall higher glycolytic reserve capacity as compared to the control LCLs and compared to the (<b>H</b>) AD-N LCLs. *p<0.001; **p<0.0001; ↕ indicates an overall statistical difference between LCL groups.